A year and a half ago (fall of 2015) we replaced the furnace and air conditioner. From what we could determine this was the third forced air furnace and second air conditioner unit for the house. As part of the installation, we changed out the two 6″ ducts feeding the second floor with 8″ ducts. The idea was to get more cold air to the second floor in the summer. It worked and for the first time the second floor and first floor temperatures were the same when the air conditioner was running. Of course, to make the system work I close down upstairs duct damper doors in the winter and open them up in the summer.
Some research suggests that cleaning heating and cooling system components (e.g., cooling coils, fans and heat exchangers) may improve the efficiency of your system, resulting in a longer operating life, as well as some energy and maintenance cost savings. However, little evidence exists that cleaning only the ducts will improve the efficiency of the system.